109Ag nanoparticles as seen with TEM 210k X and coupled with fluorescent dye and CendR peptide being taken up by cancer cells 100 X
Author: Anne-Mari Willmore, MSc
September 2013, Funding for collaboration with Prof. Bjerkvig’s lab in University of Bergen (Norway)
Norwegian-Estonian Research Cooperation Programme reached a positive funding decision regarding the joint proposal of the lab of Cancer Biology with the group of Prof. Bjerkvig in the University of Bergen (Norway) on the development of glioma stem cell like cell targeting peptides. The project is one out of 13 projects (170 total) that were recommended for funding.
EMBO Cancer YIP meeting (September 8-10, 2013)
Prof. Tambet Teesalu presented his work on the P32 binding tumor penetrating peptide and on the development of the high-throughput sequencing-based phage display platform on the EMBO Young Investigator Program Cancer Group meeting in Antalya, Turkey.
September 2013. New members joining the lab
The Laboratory of Cancer Biology continues recruiting researchers to build up a multidisciplinary team for development of cancer drugs and therapeutics. The latest members to join us are lab manager Kaarel Kurm (M.Sc. in molecular biology, University of Tartu), Ph.D. student Hedi Hunt (M.Sc. in Drug Innovation, University of Utrecht), research scientist Hideki Ikemoto (Ph. D. in chemistry, Technical University of Denmark), and bioinformatician Aleksander Sudakov (B.Sc. in bioinformatics, University of Tartu).
TEM picture of 20 nm silver nanoparticles at 65,000x of magnification
Author: Lorena Simon Gracia, PhD
TEM image of silver, palladium nanoparticles at 93,000x magnification
Author: Anne-Mari Willmore, MSc
Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor
Zanuy D, Kotla R, Nussinov R, Teesalu T, Sugahara KN, Alemán C, Haspel N.
J Struct Biol. 2013 Feb 24. doi:pii: S1047-8477(13)00043-9. 10.1016/j.jsb.2013.02.006. [Epub ahead of print]
The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles
Missirlis D, Teesalu T, Black M, Tirrell M.
PLoS One. 2013;8(1):e54611. doi: 10.1371/journal.pone.0054611. Epub 2013 Jan 17.
Application of a proapoptotic peptide to intratumorally spreading cancer therapy
Chen R, Braun GB, Luo X, Sugahara KN, Teesalu T, Ruoslahti E.
Cancer Res. 2013 Feb 15;73(4):1352-61. doi: 10.1158/0008-5472.CAN-12-1979. Epub 2012 Dec 17.
De novo design of a tumor-penetrating peptide
Alberici L, Roth L, Sugahara KN, Agemy L, Kotamraju VR, Teesalu T, Bordignon C, Traversari C, Rizzardi GP, Ruoslahti E.
Cancer Res. 2013 Jan 15;73(2):804-12. doi: 10.1158/0008-5472.CAN-12-1668. Epub 2012 Nov 14.
